The Manzoni family, a notorious mafia clan, is relocated to Normandy, France under the witness protection program, where fitting in soon becomes challenging as their old habits die hard.

A group of five Genesect have invaded the big city and pose a threat to the supply of electricity, which attracts the attention of the legendary Pokémon Mewtwo. Satoshi, Pikachu and his friends must come to the rescue when the powerful leader, a red Genesect, faces Mewtwo.